The Ubiquitin System and Cellular Protein Turnover

The ubiquitin ligase Hul5‭ ‬promotes proteasomal processivity

ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor

The 26S proteasome - from basic mechanisms to drug targeting

Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation

Fungal mechanisms for host iron acquisition

Tracing the history of the ubiquitin proteolytic system‭: The pioneering article

Synphilin-1A inhibits seven in absentia homolog‭ (‬SIAH‭) ‬and modulates alpha-synuclein monoubiquitylation and inclusion formation

Some lessons from my work on the biochemistry of the ubiquitin system

Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-kappaB precursor

Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation

The N-terminal domain of MyoD is necessary and sufficient for its nuclear localization-dependent degradation by the ubiquitin system

Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease

Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20

An endocytic mechanism for haemoglobin-iron acquisition in Candida albicans

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans.

Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells.

Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation.

Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004.

Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint.

The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity.

An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity

Synphilin Isoforms and the Search for a Cellular Model of Lewy Body Formation in Parkinson's Disease.

Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.

Two distinct ubiquitin-dependent mechanisms are involved in NF-kappaB p105 proteolysis.

Mutation analysis of the seven in absentia homolog 1 (SIAH1) gene in Parkinson's disease.

Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system.

Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.

The ubiquitin system and morphogenesis of fungal pathogens.

Ha-ras^val12 induces HSP70b transcription via the HSE/HSF1 system, but HSP70b expression is suppressed in Ha-ras^val12-transformed cells

Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding.

The ubiquitin proteolytic system: from an idea to the patient bed.

Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.

The ubiquitin proteolytic system. From a vague idea, through basic mechanisms, and onto human diseases and drug targeting.

Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition.

Intracellular protein degradation: from a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting (Nobel lecture).

E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1.

Early work on the ubiquitin proteasome system, an interview with Aaron Ciechanover. Interview by CDD.

Early work on the ubiquitin proteasome system, an interview with Avram Hershko. Interview by CDD.

Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.

The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle.

The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture).

Ubiquitin-proteasome-mediated degradation, intracellular localization, and protein synthesis of MyoD and Id1 during muscle differentiation.

Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation.

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.

Coevolution of cyclin Pcl5 and its substrate Gcn4.

A family of Candida cell surface haem-binding proteins involved in haemin and haemoglobin-iron utilization.

Affinity purification of mitotic anaphase-promoting complex/cyclosome on p13Suc1.

Glycogen synthase kinase 3b modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: IMPLICATIONS FOR PROTEASOMAL FUNCTION AND LEWY BODY FORMATION.

N-terminal ubiquitination.

Proteolysis: from the lysosome to ubiquitin and the proteasome.

Role for the SCFCDC4 ubiquitin ligase in Candida albicans morphogenesis.

The ubiquitin-proteasome system--micro target for macro intervention?

Dual effects of IkappaB kinase betamediated phosphorylation on p105 Fate: SCFβ-TrCP-dependent degradation and SCFβ-TrCP-independent processing.

The tumor suppressor protein p16INK4a and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquit

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by a-synuclein.

The cellcycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27.

SKP2 is required for ubiquitinmediated degradation of the CDK inhibitor p27.

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.